Can we treat keratoconus without surgery?

The development of pharmacological agents that can induce corneal cross-linking through simple eye drops is a major area of pharmaceutical research. These "chemical" cross-linkers aim to mimic the effect of UV-based CXL but with a significantly lower side-effect profile and zero surgical risk.

How is the Ophthalmic Drug Delivery Market supporting keratoconus?

Growth in the Ophthalmic Drug Delivery Market for 2024 is centered on sustained-release riboflavin inserts. These inserts are placed in the conjunctival sac, providing a constant supply of the vitamin to the cornea. This technology is a prerequisite for "natural light" cross-linking protocols, where patients simply spend time outdoors instead of being subjected to intense artificial UV light in a clinic.

The role of anti-inflammatory drops in stabilizing the cone

While not a cure, managing ocular surface inflammation and allergies is vital. Chronic eye rubbing, often driven by allergic conjunctivitis, is a known driver of ectasia. Integrated pharmacological management that includes high-potency mast-cell stabilizers is now a standard part of the keratoconus treatment regimen.

  • Research into copper-based eye drops to increase natural cross-linking.
  • Development of collagen-stimulating topical agents.
  • Phase II trials for LOX (Lysyl Oxidase) activating drops.

2024/2025 Outlook

For 2025, we anticipate the results of trials for "at-home" CXL kits. These would involve prescription drops and low-intensity LED goggles, potentially moving the treatment from the surgical suite to the patient's living room for mild-to-moderate cases.

Author: Sofiya Sanjay

Designation: Healthcare Research Consultant, Market Research Future

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